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Healio Rheuminations


Aug 25, 2022

How is the synovial fluid produced? Who figured it out? It’s a ripping yarn involving corpses, cats, anti-hypertensives, steroids and streptococcus.

Brought to you by Tremfya.

  • Intro :11
  • Today’s episode :15
  • Synovium 101 :22
  • Overview of the synovium and synovial fluid 2:06
  • How they figured it out? Dr. Marian Ropes 5:37
  • Investigating synovial fluid 7:46
  • Cows experiment and where synovial fluid comes from 11:25
  • Clinical review of synovial fluid 14:57
  • What’s inside the fluid? 18:54
  • What makes up the fluid? 20:51
  • How do things get out of the synovium? 23:19
  • How are things absorbed into the synovium? 27:21
  • How well do steroids get picked up systemically? 29:39
  • Summary 32:30
  • Thank you 34:59

Disclosures: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to Dr. Brown at rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Edwards JC. J Anat. 1994;184:493-501.

Rhinelander FW, et al. J Clin Invest. 1939;doi:10.1172/JCI101011.

Shaffer MF, et al. J Exp Med. 1939;doi:10.1084/jem.70.3.293.

Stout A, et al. PM R. 2019;doi:10.1002/pmrj.12042.