Preview Mode Links will not work in preview mode

Healio Rheuminations


May 20, 2020

This episode dives into the rare Whipple’s disease, focusing on the articular manifestations of this infectious masquerader and when a rheumatologist should consider it in the differential.

Brought to you by GSK. Considering a treatment change for patients with active SLE? Learn about a treatment option for your patients at treatfortodayandtomorrow.com.

  • Intro :20
  • In this episode :28
  • Background on the organism 5:25
  • An important point when making the diagnosis 7:48
  • Who gets infected? 8:55
  • What is Whipple’s disease? 11:48
  • This disease is fatal 15:53
  • A look at the joints 16:28
  • What happens when you give these patients immunosuppression? 26:36
  • How to diagnose 28:38
  • Summary so far 31:00

Brought to you by GSK. Consider the long-term impact of disease activity, flares and corticosteroid use on patients with active SLE. Learn more now at treatfortodayandtomorrow.com

  • Other organ manifestations of Whipple’s disease 32:08
  • Summary and take-home 44:36

Disclosure: Brown reports no relevant financial disclosures.

We’d love to hear from you! Send your comments/questions to rheuminationspodcast@healio.com. Follow us on Twitter @HRheuminations @AdamJBrownMD @HealioRheum

References:

Bousbia S, et al. Emerg Infect Dis. 2010;16:258-63.

Chan RY, et al. Ophthalmology. 2001;108:2225-2231.

Dobbins 3rd WO, et al. Arthritis Rheum. 1987;30:102-105.

Durand DV, et al. Medicine (Baltimore). 1997;76:170-84.

Fenollar F, et al. BMC Infect Dis. 2011;11:171.

Feurle GE, et al. Eur J Clin Invest. 1979;9:385-389.

Geissdörfer W, et al. J Clin Microbiol. 2012;50:216-22.

Guérin A, et al. Elife. 2018;7:e32340.

Heffner DK. Lancet. 2007;370:738-9; author reply 739.

Keita AK, et al. PLoS Negl Trop Dis. 2011;5:e1403.

Lagier JC, et al. Medicine (Baltimore). 2010;89:337-345.

Lozupone C, et al. Am J Respir Crit Care Med. 2013;187:1110-7.

McAllister Jr. HA, Fenoglio Jr. JJ. Circulation. 1975;52:152-6.

O’Duffy JD, et al. Arthritis Rheum. 1999;42:812-817.

Puéchal X. Joint Bone Spine. 2016;83:631-635.

Puéchal X, et al. Arthritis Rheum. 2002;46:1130-1132.

Puéchal X, et al. Arthritis Rheum. 2007;56:1713-1718.

Raheja AA, et al. Clin Imaging. 2010;34:143-147.

Ramos JM, et al. J Med Case Rep. 2015;9:165.

Raoult D, et al. Emerg Infect Dis. 2010;16:776-82.

Schöniger-Hekele M, et al. Appl Environ Microbiol. 2007;73:2033-2035.

Stein A, et al. Am J Respir Crit Care Med. 2013;188:1036-7.

Additional resource:

Neurosigns.org’s video on oculomasticatory myorhythmia can be viewed at: https://www.youtube.com/watch?v=Zwb5bt749Jo