Aug 29, 2024
In the third episode of the NSAIDs saga, we focus on COX-2 inhibition! Did the hopes and dreams of selective COX-2 inhibition pan out? What can the rise and fall of VIOXX teach us about physiology?
- Intro 0:11
- Recap of part 1 & 2 0:28
- In this episode 1:44
- Cyclooxygenase 2 (COX-2) and the rat experiment 3:12
- What do we...
Jun 26, 2024
In this episode, we dive into the story of aspirin and the development of ibuprofen, ending with the experiments that showed the mechanism of how aspirin actually works.
- Intro 0:12
- Review of part 1 0:28
- In this episode 1:04
- Blocking prostaglandins and willow leaves 2:26
- Edward Stone 3:45
- Johann Andreas Buchner 4:16
- The...
May 16, 2024
Humans have had an insatiable appetite for inhibiting production of prostaglandins for centuries! This series delves into the history of aspirin and NSAIDs, looking at the understanding of the prostaglandin pathway.
· Intro 0:12
· In this episode 0:23
· What are NSAIDs? 0:53
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Apr 18, 2024
This episode digs into the pathophysiology of urticaria vasculitis from anti-C1q to the story of bradykinin.
· Intro 0:11
· In this episode 0:22
· Review of episode 83 1:23
· Listen to previous episode, The Complement System for Dunces 4:09
· Anti-C1q antibodies 6:26
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Feb 28, 2024
Is it an allergy or an autoimmune vasculitis, or a little of both? Find out the story of urticarial vasculitis, how this disease was recognized and eventually sorted out from other types of urticaria.
· Intro 0:12
· In this episode 0:21
· Case study 1:22
· Chronic spontaneous urticaria,...